Shanghai Saierxin Biomedical Technology

1) Autoimmune diseases (AID);
2) Neurodegenerative diseases or disorders (NDD)。
There is a huge unmet medical need in these disease fields. Such diseases are lack or have no effective treatments, such as ALS patients with a limited survival time and poor quality of life. Patients with such diseases have very urgent need for the effective medications to solve their medical problems. NDD and AID often overlap in many pathophysiological aspects.


Autoimmune Diseases,AID

Autoimmune diseases are abnormal immune responses in the body that attack normal cells, tissues, or organs. It is estimated currently there are at least 80 autoimmune diseases. AIDs can happen anywhere in the body. The common symptoms include mild fever and feeling tired. Symptoms often appear and resolve rapidly.

The so-called abnormal immunity is to attack parts of human bodies. The antibodies of the immune system in the human body originally attack and eliminate foreign antigens or abnormal cells (such as tumor cells), which is a physiological mechanism to protect the body. However, in some cases, the immune system may produce antibodies against normal cells in its body, causing abnormal excessive inflammation or tissue damage, which in turn affects the health of the body and causes disease.

The etiological causes of AID are still unclear. Certain autoimmune diseases, such as familial lupus erythematosus and, in some cases, are precipitated by infection or other environmental factors. Common diseases include celiac disease, type 1 diabetes, Graves’ disease, inflammatory bowel disease, multiple sclerosis, psoriasis, rheumatoid arthritis, and systemic lupus erythematosus.

Treatment depends on the type and severity of the condition, and nonsteroidal anti-inflammatory drugs (NSAIDs) and immunosuppressants, or targeted drugs, are often used. Treatment improves symptoms, but often does not cure these diseases.

Autoimmune diseases affect a wide range of people, with approximately 24 million (7%) people in the United States affected by autoimmune diseases. It occurs more often in women than in men. It usually begins during adulthood.

Focus on diseases


Neurodegenerative Disorder,NDD

Neurodegenerative disorders (NDD) are diseases directly caused by the gradual degeneration of neurons in the brain and spinal cord. The brain and spinal cord are made of neurons, which have different functions, such as controlling movement, processing sensory information, and making decisions. Neurons in the brain and spinal cord generally do not regenerate, so excessive damage may be irreversible. NDD is caused by the loss of neurons or their myelin sheaths, which worsen over time to cause dysfunction. More and more studies have indicated that many NDDs are overlapped with autoimmune abnormalities in pathophysiology.

Focus on diseases

Multiple system atrophy

Parkinson's disease

Alzheimer's disease

Huntington's Disease